I installed Asus AI Suite on my Windows 10. When it finished installing my keyboard and mouse stopped working. I couldn't click "Restart to finish installation"  so I used my soft reset button on my case. It restarted got my post beep jumpped into bios and confirmed the my usb settings as legacy.  
Side note, the mouse and keyboard work fine in bios. As soon as I get to the win 10 screen with the date and time the mouse and keyboard dont work.

I checked my usb ports. The only ones working are the 6 2.0's on the motherboard itself. The front case 2.0 and 3.0 ports dont work also the 3.0 ports on the motherboard dont work.

Unfortunately im down untill I figure this out.

I will keep you posted

I will try to get TS on another device.

Shift + F8 during boot got me to a Windows menu where my mouse and keyboard worked. This menu lead me to system restore. The restore said it failed but upon restarting the system I got into Windows like normal and it said that the restore did take place.

Anyway WHEW!!!!!

wow, glad you got it working

This same thing happened to me when I installed windows 10 on my HTPC. I had to reinstall 10 to fix it. When you do a upgrade its a 50|50 chance it will happen.

Just another reason to stay the heck away from W10 until the service pack comes out.

I did come out and it messed with game sound and crashes now. MS never gave any details of the SP1 to any venders so this is why we don't have any updated driver's yet. They're all left to figure it out them selfs.

That's why I'm staying Win7!

I hate computers

Major system upgrades are always risky - the software interface for device drivers can change majorly between operating system versions;  Windows 10, linux sysV/systemd, being the two biggest I know of - in both those cases there are serious and longterm changes to the underlying structure.  I am more impressed that their aren't more issues with such drastic changes. Microsoft could have had less of a headache by not trying to keep legacy API inplace to be phased out and just said you need to do a clean install. (apple os 9 to 10; some linux distro)